Contents:
- Medical Video: Treating High Blood Pressure With a Fixed-Dose Combination Pill in Sri Lanka
- The role of antihypertensive combination drugs in the treatment of cardiovascular diseases
Medical Video: Treating High Blood Pressure With a Fixed-Dose Combination Pill in Sri Lanka
An antihypertensive combination drug has a function that controls blood pressure. One pill or dose contains more than one class of drug, which is indicated to treat hypertension. The combination of drugs on one pill can better control hypertension by increasing adjustment.
Use the list below as a reference for more information:
- ACE inhibitors with agents calcium channel blocking
- ACE inhibitors with thiazides
- Angiotensin II inhibitors with calcium channel blockers
- Angiotensin II inhibitors with thiazides
- Agent Antiadrenergic (center) with thiazides
- Antiadrenergic agent (peripherals) with thiazides
- Beta blockers with thiazides
- Other antihypertensive combinations
- Potassium sparing diuretics with thiazides
The role of antihypertensive combination drugs in the treatment of cardiovascular diseases
Cardiovascular disease is a major cause of global morbidity and death, due to high cardiovascular risk factors and failure to control it. Hypertension is considered the most important cardiovascular risk factor, at least 1 billion adults worldwide experience it, which is related to blood pressure and cardiovascular problems. Hypertension is associated with around 9.4 million deaths each year, with at least 45% of deaths from heart disease and 51% from stroke.
Although many antihypertensive agents are effective, hypertension remains difficult to control for most patients. Most medical hypertension guidelines (for example, some experts recommend starting antihypertensive treatment with monotherapy or combination therapy) depending on the level of hypertension and the cardiovascular risk of the patient. However, only less than ⅓ patients can control blood pressure with only one drug, even with hypertension grade 1 or 2 (according to 2013 ESH / ESC classification), and ⅔ patients need at least 2 drugs.
A combination of therapies is an attempt to get in the way counter-regulatory response which is activated by a disruption of the blood pressure mechanism when the physiological system is blocked by one drug therapy. In addition to increasing blood pressure control in the initial phase of treatment for hypertension, combination therapy has been shown to induce rapid blood pressure reduction and normalization, compared with monotherapy. This is important for patients with serious hypertension (systolic blood pressure> 160 mmHg and / or diastolic blood pressure> 100 mmHg) and patients with a high or very high cardiovascular risk profile. Every 20 mmHg increases in systolic blood pressure, about 2 times the risk of cardiovascular events. The goal of antihypertensive therapy is to improve blood pressure control and reduce the possibility of cardiovascular problems.
Therefore, it is proven that combination therapy is more beneficial than monotherapy.
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