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Medical Video: Pharmacology - DRUGS FOR DIABETES (MADE EASY)
Meglitinide is a group of drugs that have a similar response to sulfonylureas, but act in a shorter time. This medicine increase insulin secretion by pancreas. He also helps the body produce more insulin in a short time after eating. Insulin helps keep blood sugar from getting too high after eating, a problem commonly faced by people with diabetes.
Meglitinide is used for treatment type 2 diabetes in people whose sugar content is not fixed, even though the person is physically active and also eating healthy food.
Meglitinide belongs to the nateglinide and repaglinide groups.
How the meglitinide works
Meglitinide and sulfonylureas are drugs that can trigger an increase in insulin levels by the pancreas, but there are some people who have problems with weight and blood sugar low due to the use of sulfonylureas. Meglitinide does not cause weight loss and low blood sugar if compared to sulfonylureas.
Meglitinide works quickly and does not persist for too long in the body, so this drug is good for people who cannot eat regular hours every day.
Meglitinida works by stimulating the pancreas to release insulin when responding to food. This drug blocks the ATP-dependent potassium channel which activates pancreatic beta cells. This inhibition of potassium channels will depolarize the pancreatic beta cells which trigger the opening of calcium channels, resulting in the entry of calcium. Increased intracellular calcium will stimulate insulin secretion.
Meglitinida works quickly and does not stay in the body for a long time. Therefore, you should take this medicine before mealtime arrives.
What are the possible side effects of meglitinide use?
Contact 112 or emergency services if you experience:
- Difficulty breathing
- Swelling of the face, lips, tongue, or throat
- Convulsions
Contact your doctor if you experience:
- Itchy
- Symptoms of a cold as cough, runny nose, stuffy nose, or sore throat
Common side effects due to the use of this drug include:
- Blood sugar drops
- Joint pain
- Backache or headache
- Stomach ache
That needs attention
Before using meglitinide, it's a good idea to discuss it first with your doctor, if:
- You are pregnant, planning to become pregnant, or breastfeeding
- You have liver disease
Follow-up is an important part of your care and safety. Meet and contact a doctor if you experience a problem.
