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Medical Video: What is creatine kinase?
Definition
What is creatinine phosphokinase?
Creatinine is a biochemical test carried out to diagnose liver damage. Creatine phosphokinase or Creatine Phosphokinase (CPK) is found in the heart muscle, skeletal muscle, and brain. The serum CPK concentration will increase when the muscles in nerve cells are injured. CK levels will increase within 6 hours after injury. If this damage occurs repeatedly, then the CK level will increase sharply after 18 hours of injury and return to normal within 2-3 days.
CK is the main enzyme in the heart studied in patients with heart disease. To check the specifications of myocardial lesions, three types of CK isoenzymes were tested, including: CK-BB (CK1), CK-MB (CK2), CK-MM (CK3). Because the metabolic characteristics of the enzyme are known to the doctor, the time, level, and instructions for treatment will be determined.
When should I undergo creatinine phosphokinase?
This test is performed to diagnose heart injury (myocardial infarction). This test can also indicate neurological pathologies or skeletal muscle disease. When the level of CPK is high, usually skeletal muscle tissue, the heart, or brain muscle tissue is injured or stressed. Identifying the type of CPK can help the doctor determine which type of wound is experienced.
The doctor will recommend this test, if the doctor needs to:
- diagnose myocardial infection
- diagnose chest pain
- determine muscle damage
- identify dermatomyositis, muscle inflammation, and other diseases
- distinguish between malignant hyperthermia and postoperative infection
Prevention & warning
What should I know before undergoing creatinine phosphokinase?
The following are some of the factors that influence the test results:
- intramuscular injection can increase CPK levels
- exercise that is too heavy or has had surgery in the near future can also increase CPK levels
- people who have high muscle mass also tend to have high CPK levels than others, so CPK levels in men are usually higher than women
- young pregnant can reduce levels of CPK concentration
- some drugs can increase the concentration of CPK including wine, amphotericin, ampicillin, several anesthetics, anticoagulants, aspirin, ACE inhibitors, colchicine, dexamethasone, fibrates, furosemide, lidocaine, lithium, morphine, propranolol, statins, and succinylcholine
Your doctor will probably do a test to check for myocardial infarction or injury to your muscles. If you suffer a heart attack, your doctor will check the level of troponin in your blood. This is another type of protein found in the heart muscle. Today, troponin testing has been replaced with a CPK test in diagnosing myocardial infarction because troponin tests are sensitive and have high specificity.
Blood tests and other EKGs can also be prescribed. Because CPK may increase the risk of thyroid problems, alcohol abuse, or kidney failure, your doctor will take another test to check for the disorder you are experiencing.
It is important to understand warnings and precautions before carrying out this test. If you have questions, please ask your doctor for more information.
Process
What should I do before undergoing creatinine phosphokinase?
The doctor will explain the procedure for carrying out this test. The doctor will also discuss the reasons and importance of taking blood through this vein to diagnose myocardial infarction. There are no restrictions on eating or drinking for you before this test is done.
What is the process of creatinine phosphokinase?
The doctor will take your blood sample and put it in a red-covered tube. Usually blood samples will be taken every day for three days then once a week. The doctor will change the area where the blood sample was taken. You must follow the doctor's instructions properly to prevent hemolysis. You should record the date and time of the test carried out intramuscularly. You also have to record the date and time when doing a blood test on a special note. This will help you to interpret the increase or decrease in the enzyme.
What should I do after undergoing creatinine phosphokinase?
You should put a sanitary napkin in your hand and gently squeeze the injection area to stop the blood. If you have questions about this process, please consult with a doctor for more information.
Explanation of Test Results
What do the test results mean?
Normal results
Total CPK:
- adults and parents (men): 55-170 units / L or 55-170 units / L (SI units)
- adults and people (women): 30-135 units / L or 30-135 units / L (SI units). Higher numbers after exercise
- baby: 68-580 units / L (SI units)
Other isoenzymes:
- CK-MM: 100%
- CK-MB: 0%
- CK-BB: 0%
Abnormal results
- increased CK concentration: pain or injury that affects the heart muscle, skeletal muscle, and brain
- increased concentration of CK-BB isoenzymes: diseases of the central nervous system, adenocarcinoma (especially the breast and lungs), pulmonary embolism
- increased levels of CK-MB isoenzymes; acute myocardial infarction, cardiac aneurysm surgery, defibrillation, inflammation of the heart muscle, ventricular arrhythmias, ischemic heart disease
- increased concentrations of CK-MM isoenzymes: rhabdomyolysis, muscular dystrophy, muscular inflammation, recent surgery, electromechanical, intramuscular, deep wounds, rapturous delirium alcohol levels, malignant hyperthermia, recent shock, electrical therapy for convulsions, shock, hypokalemia, hypothyroidism, trauma
Depending on the laboratory of your choice, the normal range of these tests can vary. Discuss the questions you have about the results of your health test with your doctor.
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