Contents:
- Medical Video: Pharmacology - ANTIARRHYTHMIC DRUGS (MADE EASY)
- How does group III antiarrhythmia work?
- What are the side effects of antiarrhythmic group III?
- Things to note
Medical Video: Pharmacology - ANTIARRHYTHMIC DRUGS (MADE EASY)
Medications that prevent or treat cardiac arrhythmias are called antiarrhythmics. Antiarrhythmic drugs are classified according to their use in 5 groups.
Group III includes potassium channel blockers with effects that extend the potential action. This causes an extension of the QT interval, which increases the risk Torsades de Pointes (TDP), ventricular arrhythmias that can be deadly. Class III agents commonly used for the maintenance of normal sinus rhythms include:
- Amiodarone
- Dronedarone
- Sotalol
- Dofetilide
How does group III antiarrhythmia work?
Potassium channel blockers work by inhibiting K + channel which increases the refractory period. This increases the duration without affecting phase 0 and resting the membrane potential. Potassium channel blockers includes class III antiarrhythmic compounds that bind and block potassium channel responsible for phase 3 repolarization. Inhibiting channels slows repolarization and results in an increase in the duration of potential actions and effective refractory periods.
What are the side effects of antiarrhythmic group III?
All of these compounds, such as group III compounds, prioritize proarrhythmic and antiarrhythmic. For example, increasing the duration of potential action can produce Torsades de Pointes (type of ventricular tachycardia) especially in patients with syndrome long-QT. Amiodarone, due to its class IV effects, can cause obstacles bradycardia and antriventricular, and has contraindications to patients with cardiac obstruction or sinoatrial node dysfunction. Side effects that you can experience include:
- Extension of the QT interval
- Because it is similar to thyroxine, drugs can interfere with thyroid function, causing hypo or hyperthyroidism
- As a result of the larger, bound, and deposited Vd on the cornea, it causes vision problems and photophobia
- Having a tendency to deposit on the skin, can make it sensitive to sunlight. Discoloration occurs in parts exposed to prolonged administration (due to iodine content)
- In prolonged administration, lung fibrosis can occur
- Liver damage can occur due to metabolism in the liver
Things to note
Always consult a doctor before using group III antiarrhythmia. Inform your doctor if you are or planning to become pregnant or breastfeeding. Also tell your doctor what medications you use, including natural and herbal supplements. Tell your doctor if you have an allergy to group III antiarrhythmic treatment.
Hello Health Group does not provide medical advice, diagnosis or treatment.
